Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TPI1 | P60174 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470417 | 0.97 | LPAR3 (0.39) | LPAR3LPAR1LPAR2FBP1CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL27519730 | 0.95 | LPAR3 (0.38) | LPAR3LPAR1LPAR2FBP1CYP2C19 | |
| Phosphoric Acid SCHEMBL17477136 | 0.84 | TSHR (0.39) | CYP2C19LMNAFDPS | |
| SCHEMBL5974079 | 0.81 | LPAR3 (0.39) | LPAR3LPAR1LPAR2FBP1TPI1 | |
| SCHEMBL2472181 | 0.81 | ALDH1A1 (0.37) | LPAR3LPAR1LPAR2CYP2C19LMNA | |
| SCHEMBL13103978 | 0.80 | LPAR3 (0.32) | LPAR3LPAR1LPAR2FBP1 | |
| Biphenyl SCHEMBL27702377 | 0.80 | S1PR1 (0.51) | S1PR1S1PR3LMNAS1PR4S1PR5 | |
| SCHEMBL6840461 | 0.79 | SAT1 (0.35) | CYP2C19LMNAFDPS | |
| SCHEMBL2782188 | 0.79 | TP53 (0.36) | CYP2C19LMNAFDPS | |
| SCHEMBL9264971 | 0.79 | CYP2C19 (0.35) | CYP2C19LMNAFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104039927-B | The preparation method of melamine phosphate flame retardant | 江苏苏利精细化工股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| WO-2016016851-A1 | MELT POLYMERIZED POLYCARBONATE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-02-04 | — | — | WO | disclosed |