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Sugi Predict / Compounds / SCHEMBL17478971

SCHEMBL17478971

SCHEMBL17478971

Cc1cc(O)nc2ccc(NC(=O)c3cc(S(=O)(=O)N4CCC(N(C)C)C4)ccc3N3CCOCC3)cc12

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.52
▸ HPGD P15428 3/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ LMNA P02545 2/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ HSD17B10 Q99714 2/20 0.47
▸ HTT P42858 1/20 0.47
▸ GBA1 P04062 3/20 0.44
▸ MAPT P10636 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ RAD52 P43351 1/20 0.43
▸ GLA P06280 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17479128 0.95 ALDH1A1 (0.54) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478705 0.89 ALDH1A1 (0.63) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL19667031 0.88 ALDH1A1 (0.56) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478607 0.86 ALDH1A1 (0.70) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478809 0.86 ALDH1A1 (0.59) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478746 0.86 ALDH1A1 (0.63) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478858 0.85 ALDH1A1 (0.64) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17479699 0.85 LMNA (0.53) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
Trifluoroacetic Acid SCHEMBL17478709 0.84 ALDH1A1 (0.54) ALDH1A1HPGDNPSR1SMN1; SMN2LMNA
SCHEMBL17478987 0.84 PRNP (0.52) ALDH1A1HPGDSMN1; SMN2LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106573915-B Compounds active against bromodomains 纽韦卢森公司 2020-12-25 — — CN claimed
US-10752640-B2 Compounds active towards bromodomains NUEVOLUTION A/S (DK) 2020-08-25 — — US claimed
US-20170349607-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION A/S (DK) 2017-12-07 — — US claimed
EP-3174868-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS Nuevolution A/S (DK) 2017-06-07 — — EP claimed
WO-2016016316-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION A/S (DK) 2016-02-04 — — WO claimed
US-10752640-B2 Compounds active towards bromodomains NUEVOLUTION A/S (DK) 2020-08-25 — — US disclosed
US-20170349607-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION A/S (DK) 2017-12-07 — — US disclosed
US-20170349607-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS NUEVOLUTION A/S (DK) 2017-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170349607-A1 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS BRD4, BRD3, BRDT ALDH1A1 3848/4885HPGD 2141/4885NPSR1 4111/4885
US-10752640-B2 Compounds active towards bromodomains BRD4, BRD3, BRDT ALDH1A1 3848/4885HPGD 2141/4885NPSR1 4111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.