Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MME | P08473 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17479509 | 0.85 | RAB9A (0.35) | KDM4EALDH1A1KMT2ATSHRS1PR3 | |
| SCHEMBL17479462 | 0.77 | P4HTM (0.49) | KDM4EALDH1A1KMT2ARAB9AMME | |
| SCHEMBL17479494 | 0.75 | P4HTM (0.50) | KDM4EALDH1A1MME | |
| SCHEMBL1965385 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1KMT2ATSHRS1PR3 | |
| SCHEMBL19138073 | 0.74 | ALDH1A1 (0.38) | KDM4EALDH1A1TSHRS1PR3S1PR2 | |
| SCHEMBL17295770 | 0.73 | CPB2 (0.42) | KDM4EALDH1A1KMT2ATSHRS1PR3 | |
| Lithium SCHEMBL17479466 | 0.73 | P4HTM (0.49) | KDM4EALDH1A1KMT2ARAB9AMME | |
| SCHEMBL31082813 | 0.73 | RAB9A (0.35) | KDM4EALDH1A1KMT2ATSHRS1PR3 | |
| SCHEMBL19874204 | 0.73 | KDM4E (0.37) | KDM4EALDH1A1TSHRS1PR3S1PR2 | |
| SCHEMBL19874206 | 0.73 | KDM4E (0.37) | KDM4EALDH1A1TSHRS1PR3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180317-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016015593-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-02-04 | — | — | WO | disclosed |