Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL5827542 | 0.81 | TDP1 (0.44) | TDP1SIRT3ALDH1A1KDM4EMAPT | |
| SCHEMBL36668757 | 0.78 | TDP1 (0.71) | TDP1SIRT3MKNK1MKNK2ALDH1A1 | |
| SCHEMBL286483 | 0.78 | TDP1 (0.71) | TDP1SIRT3MKNK1MKNK2ALDH1A1 | |
| SCHEMBL27606205 | 0.78 | UMPS (0.44) | TDP1SIRT3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL27588394 | 0.78 | UMPS (0.44) | TDP1SIRT3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6784339 | 0.78 | UMPS (0.44) | TDP1SIRT3LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6790961 | 0.78 | UMPS (0.44) | TDP1SIRT3LMNASMN1; SMN2ALDH1A1 | |
| Ribose (Furanose) SCHEMBL15881395 | 0.76 | TDP1 (0.35) | TDP1SIRT3LMNASMN1; SMN2ALDH1A1 | |
| Ribose (Furanose) SCHEMBL18185139 | 0.76 | F7 (0.59) | SIRT3MKNK1MKNK2LMNASMN1; SMN2 | |
| Ribose (Furanose) SCHEMBL14321532 | 0.76 | F7 (0.59) | SIRT3MKNK1MKNK2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174551-A1 | AGENTS FOR USE IN TREATING LIVER AND PANCREATIC CANCER | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III (ES) | 2017-06-07 | — | — | EP | claimed |
| WO-2016016391-A1 | AGENTS FOR USE IN TREATING LIVER AND PANCREATIC CANCER | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (ES) | 2016-02-04 | — | — | WO | claimed |