Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | HK1 | P19367 | 2/20 | 0.38 |
| ▸ | HK2 | P52789 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL502905 | 0.86 | KDM4C (0.37) | TDP1HK1HK2KDM4CSLC5A2 | |
| Ribose (Furanose) SCHEMBL17479515 | 0.81 | TDP1 (0.47) | TDP1SIRT3KDM4EALDH1A1MAPT | |
| SCHEMBL5827543 | 0.79 | SIRT3 (0.41) | TDP1SIRT3SLC5A2MEN1ALDH1A1 | |
| SCHEMBL8973945 | 0.78 | PYGL (0.43) | SLC5A2 | |
| SCHEMBL258230 | 0.78 | TDP1 (0.68) | TDP1SIRT3KDM4CDHODHKDM4E | |
| SCHEMBL29571308 | 0.78 | TDP1 (0.68) | TDP1SIRT3KDM4CDHODHKDM4E | |
| Ribose (Furanose) SCHEMBL19717961 | 0.77 | NAPRT (0.53) | HK1HK2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1536025 | 0.76 | TDP1 (0.66) | TDP1SIRT3KDM4CDHODHKDM4E | |
| Ribose (Furanose) SCHEMBL502577 | 0.76 | ALDH1A1 (0.58) | TDP1SIRT3HK1HK2ALDH1A1 | |
| Ribose (Furanose) SCHEMBL19475127 | 0.74 | TSHR (0.39) | HK1HK2SLC5A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638123-B1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER REC TECH LTD (GB) | 2006-12-27 | — | — | EP | disclosed |
| US-5977065-A | FROM A PRODRUG | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5780585-A | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| US-5633158-A | CULTURE PRODUCT; GENETIC ENGINEERING | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1997-05-27 | — | — | US | disclosed |
| EP-0638123-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1995-02-15 | — | — | EP | disclosed |
| EP-0540263-A1 | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008288-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1993-04-29 | — | — | WO | disclosed |