Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA4 | P22748 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | PCNA | P12004 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CASP2 | P42575 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24917491 | 0.94 | CA12 (0.32) | CA12CA1CA2CA4CA9 | |
| SCHEMBL24916957 | 0.94 | CA12 (0.32) | CA12CA1CA2CA4CA9 | |
| SCHEMBL19704124 | 0.92 | HPGD (0.35) | HPGDKMT2ACASP2L3MBTL1CNR1 | |
| SCHEMBL17739922 | 0.92 | HPGD (0.35) | HPGDKMT2ACASP2L3MBTL1CNR1 | |
| SCHEMBL24916681 | 0.91 | HPGD (0.32) | CA12CA1CA2CA4CA9 | |
| SCHEMBL17740140 | 0.88 | CASP2 (0.46) | HPGDEPHX2CASP2L3MBTL1 | |
| SCHEMBL17739921 | 0.88 | CASP2 (0.46) | HPGDEPHX2CASP2L3MBTL1 | |
| SCHEMBL25978334 | 0.88 | CA2 (0.36) | CA12CA1CA2CA4CA9 | |
| SCHEMBL25523395 | 0.88 | CA2 (0.36) | CA12CA1CA2CA4CA9 | |
| SCHEMBL24630303 | 0.87 | ALDH1A1 (0.30) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249186-B2 | Cytotoxic peptides and antibody drug conjugates thereof | PFIZER INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249186-B2 | Cytotoxic peptides and antibody drug conjugates thereof | PFIZER INC. (US) | 2016-02-02 | — | — | US | disclosed |