Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.42 |
| ▸ | KLK1 | P06870 | 6/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20979650 | 0.89 | F11 (0.43) | F11KLK1ALOX5PTPN1CHEK2 | |
| SCHEMBL17480784 | 0.89 | F11 (0.52) | F11KLK1 | |
| SCHEMBL17480787 | 0.89 | F11 (0.52) | F11KLK1 | |
| SCHEMBL20979725 | 0.84 | F11 (0.49) | F11KLK1MLKLPRCP | |
| SCHEMBL20979584 | 0.84 | F11 (0.49) | F11KLK1MLKLPRCP | |
| SCHEMBL17477807 | 0.83 | F11 (0.58) | F11KLK1 | |
| SCHEMBL17477793 | 0.83 | F11 (0.58) | F11KLK1 | |
| SCHEMBL17477791 | 0.83 | F11 (0.58) | F11KLK1 | |
| SCHEMBL20979507 | 0.80 | F11 (0.35) | F11KLK1PTPN1PRCP | |
| SCHEMBL17480703 | 0.79 | MLKL (0.39) | F11KLK1CHEK2MLKLNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016018701-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-02-04 | — | — | WO | disclosed |