Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 6/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 5/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748828 | 0.92 | HTR6 (0.42) | HTR6CCR2ADRA2AADRA2CADRA1D | |
| SCHEMBL475562 | 0.81 | HTR6 (0.67) | HTR6CYP2C9HTR1AALK | |
| SCHEMBL5021188 | 0.81 | HTR6 (0.38) | HTR6ADRA2CADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL1748394 | 0.80 | HTR6 (0.66) | HTR6CYP2C9HTR1A | |
| SCHEMBL1748198 | 0.78 | HTR6 (0.50) | HTR6ALK | |
| SCHEMBL1748401 | 0.77 | CCR2 (0.49) | HTR6CCR2ADRA2AADRA2CADRA1D | |
| SCHEMBL1748066 | 0.75 | HTR6 (0.66) | HTR6CCR2ADRA1DADRA1AADRA1B | |
| SCHEMBL1749334 | 0.75 | HTR6 (0.50) | HTR6CCR2ADRA1DADRA1AADRA1B | |
| SCHEMBL5021092 | 0.74 | CCR2 (0.47) | HTR6CCR2ADRA2AADRA2CADRA1D | |
| SCHEMBL5321618 | 0.73 | SCN1A (0.44) | HTR6CCR2SCN1ASCN5ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604021-B2 | Substituted arylamine compounds and methods of treatment | BECKER OREN (IL) | 2013-12-10 | — | — | US | disclosed |
| US-20120115850-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND METHODS OF TREATMENT | BECKER OREN (IL) | 2012-05-10 | — | — | US | disclosed |
| US-7968538-B2 | Substituted arylamine compounds and methods of treatment | GALENEA CORP. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20060205737-A1 | Substituted arylamine compounds and methods of treatment | GALENEA CORPORATION | 2006-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115850-A1 | SUBSTITUTED ARYLAMINE COMPOUNDS AND METHODS OF TREATMENT | HTR6, HTR2A, HTR3B | HTR6 1/4885CCR2 1022/4885ADRA2A 31/4885 |
| US-20060205737-A1 | Substituted arylamine compounds and methods of treatment | HTR6, HTR2A, HTR3B | HTR6 1/4885CCR2 1022/4885ADRA2A 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.