SCHEMBL17486307

SCHEMBL17486307

CCc1cc2c(cc1-c1ccc(-c3nc(-c4ccccc4)nc(-c4ccccc4)n3)cn1)C1CCC2C1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.36
MEN1 O00255 2/20 0.33
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
HPGD P15428 2/20 0.33
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 1/20 0.33
HDAC2 Q92769 1/20 0.33
PKM P14618 1/20 0.32
RORC P51449 1/20 0.32
ADORA2A P29274 4/20 0.32
ADORA1 P30542 4/20 0.32
ADORA3 P0DMS8 3/20 0.32
ADORA2B P29275 1/20 0.32
MTOR P42345 1/20 0.32
HPGDS O60760 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17485992 0.80 MEN1 (0.40) CNR2MEN1ALDH1A1MAPTHPGD
SCHEMBL17486202 0.77 RARG (0.35) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL17486348 0.76 MEN1 (0.35) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL17486212 0.75 MEN1 (0.34) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL17486208 0.72 MEN1 (0.34) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL17486345 0.72
SCHEMBL17486349 0.70 KDM4E (0.37) MEN1ALDH1A1MAPTHPGDKMT2A
SCHEMBL19295158 0.70 L3MBTL1 (0.40) CNR2MEN1ALDH1A1MAPTHPGD
SCHEMBL19295148 0.69 NPC1 (0.38) ALDH1A1MAPTHPGDNPC1RAB9A
SCHEMBL10486412 0.68 RARG (0.44) MEN1ALDH1A1MAPTHPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016015815-A1 METAL COMPLEXES MERCK PATENT GMBH (DE) 2016-02-04 WO disclosed