Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20986036 | 0.83 | ADORA2A (0.41) | ADORA2AADORA2BADORA1HSD17B10LMNA | |
| SCHEMBL2323010 | 0.78 | HDAC1 (0.40) | HSD17B10CSF1RHDAC1HTT | |
| SCHEMBL3389333 | 0.78 | GRM5 (0.49) | ADORA2AADORA1HSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL22490231 | 0.77 | ADORA2B (0.47) | ADORA2BHSD17B10LMNACSF1RALDH1A1 | |
| SCHEMBL20985870 | 0.76 | ADORA2A (0.44) | ADORA2AADORA2BADORA1HSD17B10LMNA | |
| SCHEMBL9905696 | 0.75 | ADORA2B (0.36) | NPC1RAB9AADORA2AADORA2BHSD17B10 | |
| SCHEMBL24933390 | 0.74 | GABRG2 (0.41) | CSF1R | |
| SCHEMBL15213092 | 0.73 | CSF1R (0.45) | LMNACSF1RHDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31024294 | 0.72 | FDPS (0.51) | ADORA2AADORA2BADORA1HSD17B10HTR2C | |
| SCHEMBL10163117 | 0.72 | FDPS (0.51) | ADORA2AADORA2BADORA1HSD17B10HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |