Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 8/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488332 | 0.81 | KDR (0.40) | KDRRAF1BRAFTEKTP53 | |
| SCHEMBL17487814 | 0.80 | KDR (0.40) | KDRTEKTP53RAB9ASMN1; SMN2 | |
| SCHEMBL17487839 | 0.78 | RAB9A (0.33) | KDRRAF1TEKTP53RAB9A | |
| SCHEMBL17488143 | 0.78 | RAB9A (0.40) | KDRRAF1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL17488029 | 0.78 | RAB9A (0.43) | KDRRAF1NTRK1TP53RAB9A | |
| SCHEMBL17488153 | 0.75 | RAB9A (0.43) | KDRRAF1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL17488038 | 0.73 | KDR (0.42) | KDRRAF1BRAFTEKTP53 | |
| SCHEMBL17487851 | 0.73 | NPC1 (0.39) | KDRRAF1BRAFTEKTP53 | |
| SCHEMBL17488037 | 0.73 | KDR (0.40) | KDRRAF1BRAFTEKTP53 | |
| SCHEMBL17488145 | 0.72 | RAB9A (0.41) | KDRRAF1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |