Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16132363 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1BLMCYP2D6SLC22A2 | |
| SCHEMBL1827357 | 0.80 | L3MBTL1 (0.55) | SMN1; SMN2L3MBTL1BLMCYP2D6SLC22A2 | |
| SCHEMBL16132480 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1BLMCYP2D6SLC22A2 | |
| Hydrochloric Acid SCHEMBL17102116 | 0.79 | L3MBTL1 (0.53) | SMN1; SMN2L3MBTL1BLMCYP2D6SLC22A2 | |
| SCHEMBL11001068 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1BLMCYP2D6TSHR | |
| SCHEMBL23364963 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1BLMCYP2D6ALDH1A1 | |
| SCHEMBL30471943 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1BLMCYP2D6ALDH1A1 | |
| SCHEMBL29828412 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1BLMCYP2D6ALDH1A1 | |
| SCHEMBL17100482 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1BLMCYP2D6SLC22A2 | |
| SCHEMBL12717402 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1BLMCYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | SMN1; SMN2 3186/4885L3MBTL1 1346/4885BLM 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.