Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359039 | 0.89 | NPSR1 (0.45) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL28496822 | 0.87 | POLB (0.44) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL17490464 | 0.86 | NPSR1 (0.46) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL17490379 | 0.79 | NPSR1 (0.46) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL17490479 | 0.78 | NPSR1 (0.40) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL28359193 | 0.74 | POLB (0.45) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL10745494 | 0.73 | POLB (0.49) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL28973017 | 0.72 | POLB (0.44) | NPSR1POLBGALR2MITFALDH1A1 | |
| SCHEMBL19172750 | 0.72 | PDK1 (0.38) | ALDH1A1HPGDKMT2APDK1 | |
| SCHEMBL17490445 | 0.72 | RORC (0.44) | POLBALDH1A1HPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE49851-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2024-02-27 | — | — | US | disclosed |
| US-RE48687-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2021-08-17 | — | — | US | disclosed |
| US-RE48687-E1 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2021-08-17 | — | — | US | disclosed |
| EP-3181560-B1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN) | 2020-11-25 | — | — | EP | disclosed |
| EP-3181560-B1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO LTD (CN) | 2020-11-25 | — | — | EP | disclosed |
| US-10072002-B2 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | SHANGHAI ALLIST PHARMACEUTICALS, INC. (CN) | 2018-09-11 | — | — | US | disclosed |
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2017-07-27 | — | — | US | disclosed |
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. (CN) | 2017-07-27 | — | — | US | disclosed |
| EP-3181560-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Shanghai Allist Pharmaceuticals, Inc. (CN) | 2017-06-21 | — | — | EP | disclosed |
| EP-3181560-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Shanghai Allist Pharmaceuticals, Inc. (CN) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016015453-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | 上海艾力斯医药科技有限公司 | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210739-A1 | PYRIDINYLAMINOPYRIMIDINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | EGFR, ERBB2, ERBB4 | NPSR1 1035/4885POLB 1842/4885GALR2 4237/4885 |
| US-10072002-B2 | Pyridinylaminopyrimidine derivatives, preparation process and use thereof | EGFR, ERBB2, ERBB4 | NPSR1 1035/4885POLB 1842/4885GALR2 4237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.