SCHEMBL17498342

SCHEMBL17498342

Nc1ccc(N)c(Sc2cc(N)ccc2N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB2 P05107 2/20 0.43
ICAM1 P05362 2/20 0.43
ITGAL P20701 2/20 0.43
CASP1 P29466 3/20 0.40
PDE7A Q13946 2/20 0.40
CYP3A4 P08684 7/20 0.39
TSHR P16473 3/20 0.39
MAPK1 P28482 1/20 0.39
AAK1 Q2M2I8 1/20 0.39
ALDH1A1 P00352 5/20 0.38
RECQL P46063 3/20 0.38
MEN1 O00255 3/20 0.38
MAPT P10636 3/20 0.38
KMT2A Q03164 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
ALOX15 P16050 2/20 0.38
THRB P10828 2/20 0.38
PKM P14618 2/20 0.38
USP2 O75604 1/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17498277 0.97 ITGB2 (0.47) ITGB2ICAM1ITGALCASP1PDE7A
SCHEMBL17498298 0.87 CASP1 (0.42) ITGB2ICAM1ITGALCASP1PDE7A
SCHEMBL17498283 0.87 ALOX15 (0.47) ITGB2ICAM1ITGALCASP1CYP3A4
SCHEMBL17498330 0.87 ITGB2 (0.48) ITGB2ICAM1ITGALCASP1PDE7A
Hydrochloric Acid SCHEMBL17498331 0.85 CASP1 (0.41) ITGB2ICAM1ITGALCASP1PDE7A
SCHEMBL17498285 0.83 CASP1 (0.48) ITGB2ICAM1ITGALCASP1CYP3A4
SCHEMBL17498316 0.82 CYP1A2 (0.53) ITGB2ICAM1ITGALCYP3A4ALDH1A1
SCHEMBL5165904 0.81 CASP1 (0.44) CASP1CYP3A4TSHRALDH1A1RECQL
SCHEMBL18598786 0.81 CASP1 (0.39) ITGB2ICAM1ITGALCASP1PDE7A
SCHEMBL17498348 0.80 ALOX15 (0.41) ITGB2ICAM1ITGALCASP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016020111-A1 NOVEL OXIDATION DYE INTERMEDIATES OF THE TYPE OF OXY-, THIO-, AND AZA-BIS-BENZENES HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed
WO-2016020111-A1 NOVEL OXIDATION DYE INTERMEDIATES OF THE TYPE OF OXY-, THIO-, AND AZA-BIS-BENZENES HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed