SCHEMBL17499205

SCHEMBL17499205

C[SiH](C)Oc1ccccc1N=CCc1ccccn1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SYK P43405 4/20 0.35
AURKB Q96GD4 2/20 0.34
INCENP Q9NQS7 2/20 0.34
KDM4E B2RXH2 2/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ABCB1 P08183 1/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
HRH3 Q9Y5N1 1/20 0.33
ALDH1A1 P00352 2/20 0.32
LMNA P02545 2/20 0.32
TAAR1 Q96RJ0 1/20 0.32
ALOX15 P16050 1/20 0.32
HRH1 P35367 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499702 0.86 PKM (0.37) SYKAURKBINCENPNPC1RAB9A
SCHEMBL17499393 0.86 PKM (0.39) SYKAURKBINCENPKDM4ENPC1
SCHEMBL17499686 0.86
SCHEMBL16096261 0.86 SYK (0.45) SYKAURKBINCENPKDM4EL3MBTL1
SCHEMBL17499472 0.86 PDE4A (0.31)
SCHEMBL17499266 0.86 GABRA1 (0.32) KDM4EHRH1
SCHEMBL17499461 0.85 KDM1A (0.32) SYKAURKBINCENPALDH1A1
SCHEMBL17499758 0.83 MEN1 (0.30)
SCHEMBL17499535 0.83 SCN8A (0.41) SYKKDM4EL3MBTL1HRH3
SCHEMBL17499158 0.82 SYK (0.35) SYKAURKBINCENPKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed