SCHEMBL17499427

SCHEMBL17499427

Cc1c(CC=Nc2ccccc2O[Si](C)(C)C)cnn1C

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
BLM P54132 1/20 0.36
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499650 0.88 ALDH1A1 (0.38) KDM4EALDH1A1BLMCYP1A2CYP2D6
SCHEMBL17499213 0.84 KDM4E (0.36) KDM4EALDH1A1BLMCYP1A2CYP2D6
SCHEMBL17499159 0.83 KDM4E (0.32) KDM4EALDH1A1BLM
SCHEMBL17499579 0.79 CYP1A2 (0.44) KDM4EALDH1A1BLMCYP1A2CYP2D6
SCHEMBL17499386 0.79 KMT2A (0.30)
SCHEMBL17499576 0.79 CYP1A2 (0.44) KDM4EALDH1A1BLMCYP1A2CYP2D6
SCHEMBL17499824 0.78 KMT2A (0.33) ALDH1A1
SCHEMBL17499429 0.77 KDM1A (0.34) KDM4EALDH1A1
SCHEMBL22607510 0.76
SCHEMBL17499180 0.74 MEN1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed