SCHEMBL17499643

SCHEMBL17499643

CC(=Nc1ccccc1O[Si](C)(C)C)c1c(C)cnn1C

nearest known ligand 0.32

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.32
ALDH1A1 P00352 3/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
MAPT P10636 2/20 0.31
UBE2N P61088 1/20 0.31
LMNA P02545 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
CREBBP Q92793 1/20 0.31
HSD17B10 Q99714 1/20 0.30
RAB9A P51151 2/20 0.30
NPC1 O15118 1/20 0.30
PKM P14618 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16100650 0.87 GRIN2D (0.42) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL16101295 0.84 ESR1 (0.33) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL17499532 0.84 HTT (0.32) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL17499294 0.82 ALDH1A1 (0.33) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL16098181 0.77 HTT (0.35) HTTALDH1A1KMT2AMAPTLMNA
SCHEMBL17499269 0.77 ALDH1A1 (0.30) ALDH1A1MAPTLMNAHSD17B10RAB9A
SCHEMBL17499412 0.75 SMN1; SMN2 (0.34) ALDH1A1MAPTLMNAHSD17B10RAB9A
SCHEMBL17499485 0.74 KMT2A (0.36) HTTALDH1A1MEN1KMT2AMAPT
SCHEMBL17499476 0.73 ALDH1A1 (0.33) ALDH1A1MAPTLMNAHSD17B10RAB9A
SCHEMBL17499756 0.73 ALDH1A1 (0.34) ALDH1A1MEN1KMT2AMAPTUBE2N

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed