Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 4/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500065 | 1.00 | HIF1A (0.43) | HIF1ARAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL17374348 | 0.90 | NPC1 (0.53) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17374350 | 0.90 | NPC1 (0.53) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17374178 | 0.77 | RAB9A (0.58) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17374175 | 0.77 | RAB9A (0.58) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17374476 | 0.77 | RAB9A (0.58) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL20200053 | 0.76 | RAB9A (0.56) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL18584501 | 0.72 | NPC1 (0.51) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17381661 | 0.69 | NPC1 (0.50) | HIF1ARAB9ANPC1S1PR1FAAH | |
| SCHEMBL17381663 | 0.69 | NPC1 (0.50) | HIF1ARAB9ANPC1S1PR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |