Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MLLT1 | Q03111 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374476 | 0.92 | RAB9A (0.58) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17374175 | 0.92 | RAB9A (0.58) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17374178 | 0.92 | RAB9A (0.58) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17374348 | 0.87 | NPC1 (0.53) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17374350 | 0.87 | NPC1 (0.53) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL20200054 | 0.86 | RAB9A (0.54) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL20200063 | 0.86 | RAB9A (0.54) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL19239565 | 0.84 | RAB9A (0.54) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17374546 | 0.83 | NPC1 (0.55) | RAB9ANPC1S1PR1FAAHUSP30 | |
| SCHEMBL17381918 | 0.83 | NPC1 (0.55) | RAB9ANPC1S1PR1FAAHUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180147187-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147187-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | CFTR, ABCC2, ABCB4 | RAB9A 679/4885NPC1 165/4885S1PR1 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.