Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749914 | 0.89 | TBXAS1 (0.34) | TBXAS1FFAR1POLBL3MBTL1 | |
| SCHEMBL1750446 | 0.82 | TBXAS1 (0.34) | TBXAS1 | |
| SCHEMBL1088174 | 0.81 | TBXAS1 (0.39) | CASRTBXAS1FFAR1L3MBTL1 | |
| SCHEMBL12047346 | 0.81 | TBXAS1 (0.37) | CASRTBXAS1CA1CA2 | |
| SCHEMBL1750989 | 0.81 | TBXAS1 (0.37) | CASRTBXAS1CA1CA2 | |
| SCHEMBL1749912 | 0.80 | TBXAS1 (0.33) | CASRTBXAS1 | |
| SCHEMBL1749911 | 0.80 | TBXAS1 (0.33) | CASRTBXAS1 | |
| SCHEMBL1088179 | 0.80 | TBXAS1 (0.38) | CASRTBXAS1L3MBTL1 | |
| SCHEMBL12047351 | 0.80 | CASR (0.36) | CASRTBXAS1POLBCA1CA2 | |
| SCHEMBL1751007 | 0.80 | TBXAS1 (0.36) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968736-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | University of Pittsburgh—of the Commonwelth Systems of Higher Education (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | PITTSBURGH UNIVERSITY OF - OF THE COMMONWEALTH SYSTEM OF HIGHER | 2009-02-05 | — | — | US | disclosed |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-11-30 | — | — | US | disclosed |
| US-7122686-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2006-10-17 | — | — | US | disclosed |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-23 | — | — | US | disclosed |
| WO-2004022552-A1 | ANALOGS OF DISCODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | RRS1, RPS3A, RPS3 | CASR 1616/4885TBXAS1 1252/4885FFAR1 939/4885 |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | RRS1, RPS6KA3, RPS6KA4 | CASR 1772/4885TBXAS1 1173/4885FFAR1 715/4885 |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | DECR1, RRS1, WEE1 | CASR 3345/4885TBXAS1 641/4885FFAR1 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.