Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17267879 | 0.94 | LMNA (0.48) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL26703568 | 0.87 | LMNA (0.55) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL26703570 | 0.87 | MEN1 (0.41) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL29500232 | 0.85 | ESR1 (0.53) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL1685290 | 0.84 | ERN1 (0.47) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL6745721 | 0.83 | ESR1 (0.43) | KMT2AALDH1A1ESR1CYP3A4ESR2 | |
| SCHEMBL26703569 | 0.83 | ALDH1A1 (0.38) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL13329430 | 0.81 | KIF11 (0.42) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL7352856 | 0.81 | KMT2A (0.43) | KMT2ALMNAMEN1THRBBLM | |
| SCHEMBL28026919 | 0.80 | MAPK1 (0.39) | KMT2ALMNAMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |