Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28577323 | 0.92 | HSD11B1 (0.50) | HSD11B1HDAC1MEN1KMT2AALDH1A1 | |
| SCHEMBL29275065 | 0.92 | HSD11B1 (0.47) | HSD11B1OPRM1HDAC1ALDH1A1 | |
| SCHEMBL4809604 | 0.90 | HSD11B1 (0.51) | HSD11B1HDAC1ALDH1A1 | |
| SCHEMBL11044923 | 0.87 | NPC1 (0.46) | HSD11B1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5171006 | 0.83 | HSD11B1 (0.48) | HSD11B1OPRM1KMT2A | |
| SCHEMBL3970990 | 0.83 | HSD11B1 (0.49) | HSD11B1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3554737 | 0.81 | HSD11B1 (0.58) | HSD11B1KMT2AALDH1A1 | |
| SCHEMBL301150 | 0.81 | APP (0.61) | HSD11B1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12020420 | 0.81 | HSD11B1 (0.47) | HSD11B1APPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12745718 | 0.79 | HSD11B1 (0.46) | HSD11B1APPCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |