Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28577323 | 0.98 | HSD11B1 (0.50) | HSD11B1HDAC1ALDH1A1HDAC4SLC6A3 | |
| SCHEMBL29275065 | 0.94 | HSD11B1 (0.47) | HSD11B1HDAC1ALDH1A1HDAC4AKR1C1 | |
| SCHEMBL17508231 | 0.90 | HSD11B1 (0.46) | HSD11B1HDAC1ALDH1A1 | |
| SCHEMBL4805246 | 0.83 | HDAC4 (0.64) | HSD11B1HDAC1ALDH1A1HDAC4SLC6A3 | |
| SCHEMBL1807150 | 0.83 | AKR1C1 (0.66) | HSD11B1HDAC1ALDH1A1HDAC4SLC6A3 | |
| SCHEMBL4810246 | 0.81 | MAPT (0.47) | HSD11B1ALDH1A1HDAC4AKR1C1LMNA | |
| SCHEMBL4804303 | 0.81 | HDAC1 (0.51) | HSD11B1HDAC1ALDH1A1HDAC4AKR1C1 | |
| SCHEMBL3842811 | 0.81 | LMNA (0.55) | HSD11B1HDAC1ALDH1A1HDAC4SLC6A3 | |
| SCHEMBL11044295 | 0.81 | HSD11B1 (0.52) | HSD11B1HDAC1ALDH1A1HDAC4SLC6A3 | |
| SCHEMBL1061631 | 0.81 | AKR1C1 (0.68) | HSD11B1HDAC1ALDH1A1HDAC4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465719-B2 | Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2008-12-16 | — | — | US | disclosed |
| US-20060276505-A1 | Acylhydrazine P2X7 antagonists and uses thereof | ABBOTT LABORATORIES | 2006-12-07 | — | — | US | disclosed |
| WO-2006110516-A1 | ACYLHYDRAZIDE P2X7 ANTAGONISTS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060058282-A1 | Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2006-03-16 | — | — | US | disclosed |
| EP-1583736-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TopoTarget UK Limited (GB) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065354-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058282-A1 | Carbamic acid compounds comprising an ester or ketone linkage as hdac inhibitors | HDAC1, HDAC7, HDAC11 | HSD11B1 591/4885HDAC1 1/4885ALDH1A1 1211/4885 |
| US-20060276505-A1 | Acylhydrazine P2X7 antagonists and uses thereof | P2RX7, P2RX3, P2RX1 | HSD11B1 3076/4885HDAC1 670/4885ALDH1A1 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.