Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.45 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627734 | 0.92 | HDAC4 (0.66) | HSD11B1HDAC4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3443425 | 0.92 | HDAC4 (0.61) | HSD11B1HDAC4LMNAALDH1A1TET3 | |
| SCHEMBL4805246 | 0.90 | HDAC4 (0.64) | HSD11B1HDAC4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2321735 | 0.84 | HSD11B1 (0.59) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL75310 | 0.83 | TET3 (0.61) | HSD11B1HDAC4TET3KMT2AFBXL19 | |
| SCHEMBL2097060 | 0.83 | HSD11B1 (0.58) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1362197 | 0.82 | HDAC4 (0.55) | HSD11B1HDAC4LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL12020371 | 0.81 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL17508231 | 0.81 | HSD11B1 (0.46) | HSD11B1ALDH1A1KMT2A | |
| SCHEMBL1975025 | 0.81 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388536-A1 | 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS | HOFFMANN-LA ROCHE INC. (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4486444-A1 | 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS | F. Hoffmann-La Roche AG (CH) | 2025-01-08 | — | — | EP | disclosed |
| CN-118871422-A | 3-Alkynyl carboxamides as AEP modulators | 豪夫迈·罗氏有限公司 | 2024-10-29 | — | — | CN | disclosed |
| WO-2023165943-A1 | 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-07 | — | — | WO | disclosed |
| WO-2023165943-A1 | 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-07 | — | — | WO | disclosed |
| US-7838544-B2 | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same | INCYTE CORPORATION (US) | 2010-11-23 | — | — | US | disclosed |
| EP-2018378-A2 | HETEROCYCLIC INHIBITORS OF 11-B HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | Incyte Corporation (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137066-A2 | HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |
| US-20070270424-A1 | Heterocyclic inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 and methods of using the same | INCYTE CORPORATION | 2007-11-22 | — | — | US | disclosed |
| EP-1807348-A1 | MOLECULAR SIEVE SSZ-65 | Chevron U.S.A., Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20050040074-A1 | Hydrocarbon conversion using molecular sieve SSZ-65 | CHEVRON U.S.A. INC. | 2005-02-24 | — | — | US | disclosed |
| US-20050042159-A1 | Using molecular sieve SSZ-65 for reduction of oxides of nitrogen in a gas stream | CHEVRON U.S.A. INC. | 2005-02-24 | — | — | US | disclosed |
| US-20050042169-A1 | Molecular sieve SSZ-65 composition of matter and synthesis thereof | CHEVRON U.S.A. INC. | 2005-02-24 | — | — | US | disclosed |
| WO-2004094347-A2 | MOLECULAR SIEVE SSZ-65 | CHEVRON U.S.A. INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040187684-A1 | Using molecular sieve SSZ-65 for reduction of oxides of nitrogen in a gas stream | CHEVRON U.S.A. INC. | 2004-09-30 | — | — | US | disclosed |
| US-20040191167-A1 | Zeolite SSZ-65 composition of matter and synthesis thereof utility | CHEVRON U.S.A. INC. | 2004-09-30 | — | — | US | disclosed |
| US-20040188324-A1 | Hydrocarbon conversion using molecular sieve SSZ-65 | CHEVRON U.S.A. INC. | 2004-09-30 | — | — | US | disclosed |
| EP-0024172-B1 | ANTITUMOR AND IMMUNOSUPPRESSIVE 4-CARBAMOYLIMIDAZOLIUM-5-OLATE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND PRODUCTION THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-05-11 | — | — | EP | disclosed |
| US-4317825-A | WATER SOLUBILITY | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-02 | — | — | US | disclosed |
| EP-0024172-A1 | Antitumor and immunosuppressive 4-carbamoylimidazolium-5-olate derivatives, pharmaceutical composition and production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050040074-A1 | Hydrocarbon conversion using molecular sieve SSZ-65 | SRP72, SSU72, SRP68 | HSD11B1 1475/4885HDAC4 2545/4885LMNA 3334/4885 |
| US-20070270424-A1 | Heterocyclic inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 and methods of using the same | HSD11B1, HSD17B1, HSD17B11 | HSD11B1 1/4885HDAC4 1255/4885LMNA 2641/4885 |
| US-20250388536-A1 | 3-ALKYNYL CARBOXAMIDES AS AEP MODULATORS | CNR2, CNR1, FAAH2 | HSD11B1 3161/4885HDAC4 1844/4885LMNA 4467/4885 |
| US-20040188324-A1 | Hydrocarbon conversion using molecular sieve SSZ-65 | SRP72, SSU72, SRP68 | HSD11B1 1459/4885HDAC4 2697/4885LMNA 3300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.