Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15129327 | 0.85 | TP53 (0.57) | TP53LMNAHTTESR1IDO1 | |
| SCHEMBL10396654 | 0.85 | TP53 (0.57) | TP53LMNAHTTESR1IDO1 | |
| SCHEMBL31074209 | 0.81 | ADRA2C (0.50) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL3192743 | 0.81 | ADRA2C (0.50) | TP53LMNAHTTIDO1TDO2 | |
| SCHEMBL14677340 | 0.80 | TP53 (0.61) | TP53LMNAHTTESR1IDO1 | |
| SCHEMBL14981213 | 0.77 | TP53 (0.57) | TP53LMNAHTTESR1IDO1 | |
| SCHEMBL1143487 | 0.77 | TP53 (0.62) | TP53LMNAHTTESR1IDO1 | |
| SCHEMBL412260 | 0.77 | AOC3 (0.43) | LMNAHTTIDO1TDO2KMT2A | |
| SCHEMBL11018686 | 0.76 | LMNA (0.47) | TP53LMNAHTTIDO1TDO2 | |
| Hydrochloric Acid SCHEMBL3447755 | 0.76 | AOC3 (0.42) | LMNAHTTIDO1TDO2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |