Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246457 | 0.78 | CYP3A4 (0.39) | CYP3A4CYP2E1CYP2A6CYP1A2CYP2C9 | |
| SCHEMBL10904420 | 0.78 | GAA (0.47) | CYP3A4CYP2E1CYP2A6ALDH1A1SMN1; SMN2 | |
| SCHEMBL15218939 | 0.73 | NR4A1 (0.54) | ICMTCYP3A4CYP2E1CYP2A6CYP1A2 | |
| SCHEMBL2451209 | 0.70 | PSEN1 (0.44) | KCNH2 | |
| SCHEMBL2517633 | 0.70 | PSEN1 (0.36) | CYP3A4CYP2C9CYP2C19CYP2D6KCNH2 | |
| SCHEMBL196349 | 0.70 | ALDH1A1 (0.56) | CYP3A4CYP2E1CYP2A6CYP1A2CYP2C9 | |
| SCHEMBL61338 | 0.68 | CYP3A4 (0.57) | ICMTCYP3A4CYP2E1CYP2A6CYP1A2 | |
| SCHEMBL15218938 | 0.68 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HTTKDM4EKMT2A | |
| SCHEMBL8502061 | 0.67 | CYP3A4 (0.47) | ICMTCYP3A4CYP2E1CYP2A6CYP1A2 | |
| SCHEMBL10902395 | 0.67 | ICMT (0.53) | ICMTCYP3A4CYP2E1CYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611805-A1 | FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT | Takeda Pharmaceutical Company Limited (JP) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029991-A1 | FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-08 | — | — | WO | disclosed |