Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 17/20 | 0.58 |
| ▸ | HPGD | P15428 | 12/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 8/20 | 0.54 |
| ▸ | USP2 | O75604 | 4/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11947826 | 0.83 | HSD17B10 (0.57) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL17518848 | 0.82 | ALDH1A1 (0.65) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL30556672 | 0.80 | ALDH1A1 (0.77) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL11947809 | 0.80 | HSD17B10 (0.64) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL136881 | 0.79 | PLD1 (0.56) | ALDH1A1HSD17B10SMN1; SMN2PLD1 | |
| SCHEMBL24435218 | 0.77 | ALDH1A1 (0.73) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL26049676 | 0.77 | ALDH1A1 (0.57) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL19558107 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL30212352 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HSD17B10HPGDCYP1A2TSHR | |
| SCHEMBL25561240 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HSD17B10HPGDCYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809545-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160046581-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046581-A1 | Factor XIa Inhibitors | F11, F12, TFPI | ALDH1A1 2920/4885HSD17B10 1681/4885HPGD 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.