Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.79 |
| ▸ | MAOB | P27338 | 5/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340631 | 0.92 | MAOA (0.67) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL12938917 | 0.89 | HDAC6 (0.78) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL1080466 | 0.86 | HDAC6 (1.00) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL12938807 | 0.86 | HDAC6 (0.84) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL12938916 | 0.85 | HDAC6 (0.72) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL1002965 | 0.84 | HDAC6 (0.71) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL19970051 | 0.83 | CHRM2 (0.80) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL13944387 | 0.81 | KDM4E (0.65) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL20960970 | 0.80 | HDAC6 (0.69) | MAOAMAOBHDAC6HDAC1HDAC3 | |
| SCHEMBL8803935 | 0.80 | CYP1A2 (0.73) | MAOAMAOBHDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011614-B2 | Bis-β-carboline compound and preparation method, pharmaceutical composition and use thereof | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD (CN) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | BRCA1, CA7, DCK | MAOA 3499/4885MAOB 1253/4885HDAC6 1023/4885 |
| US-10011614-B2 | Bis-β-carboline compound and preparation method, pharmaceutical composition and use thereof | BRCA1, CA7, DCK | MAOA 3791/4885MAOB 2309/4885HDAC6 1015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.