Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20960970 | 0.91 | HDAC6 (0.69) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Mebhydrolin SCHEMBL29808874 | 0.89 | ADRA2A (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Mebhydrolin SCHEMBL29802 | 0.89 | ADRA2A (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| Mebhydrolin SCHEMBL2141004 | 0.88 | ALDH1A1 (1.00) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL20340631 | 0.87 | MAOA (0.67) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL12938922 | 0.85 | HDAC6 (0.78) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL16624342 | 0.85 | CHRM2 (0.59) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL20960968 | 0.84 | HDAC6 (0.77) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL8038611 | 0.84 | CHRM2 (0.85) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL17517481 | 0.83 | MAOA (0.79) | CHRM2HTR1AADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322122-B2 | Methods and compositions for treating degenerative and ischemic disorders | THE GENERAL HOSPITAL CORPORATION (US) | 2019-06-18 | — | — | US | disclosed |
| US-20180071279-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | THE GENERAL HOSPITAL CORPORATION | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071279-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | PINK1, PC, PCK2 | CHRM2 958/4885HTR1A 821/4885ADRA2A 1645/4885 |
| US-10322122-B2 | Methods and compositions for treating degenerative and ischemic disorders | PINK1, PC, PCK2 | CHRM2 958/4885HTR1A 821/4885ADRA2A 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.