Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 20/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 20/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 20/20 | 1.00 |
| ▸ | GABRA3 | P34903 | 19/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 19/20 | 1.00 |
| ▸ | GABRA5 | P31644 | 18/20 | 0.91 |
| ▸ | GABRA6 | Q16445 | 15/20 | 0.91 |
| ▸ | GABRA4 | P48169 | 11/20 | 0.91 |
| ▸ | GABRP | O00591 | 4/20 | 0.72 |
| ▸ | GABRD | O14764 | 4/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.72 |
| ▸ | GABRE | P78334 | 4/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.72 |
| ▸ | UBE2N | P61088 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352291 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29635240 | 0.84 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9075631 | 0.78 | GABRA1 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL11288083 | 0.76 | GABRA1 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL10707136 | 0.76 | GABRA1 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL20340622 | 0.76 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL10707662 | 0.75 | GABRA1 (0.76) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL10708806 | 0.74 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7380799 | 0.74 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9839008 | 0.74 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011614-B2 | Bis-β-carboline compound and preparation method, pharmaceutical composition and use thereof | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | XINJIANG HUASHIDAN PHARMACEUTICAL RESEARCH CO., LTD (CN) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039845-A1 | BIS-B-CARBOLINE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | BRCA1, CA7, DCK | GABRA1 2323/4885GABRG2 3333/4885GABRB3 1560/4885 |
| US-10011614-B2 | Bis-β-carboline compound and preparation method, pharmaceutical composition and use thereof | BRCA1, CA7, DCK | GABRA1 2755/4885GABRG2 3738/4885GABRB3 2070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.