Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752631 | 0.91 | MAPT (0.44) | PPARGPPARDCHEK2ALDH1A1MAPT | |
| SCHEMBL1751677 | 0.89 | CHEK2 (0.41) | HRH3L3MBTL1PPARGPPARDCHEK2 | |
| SCHEMBL15004677 | 0.88 | KCNH2 (0.42) | KCNH2HRH3TDP1L3MBTL1TBXAS1 | |
| SCHEMBL9212796 | 0.86 | PIK3CA (0.44) | KCNH2HRH3TDP1L3MBTL1TBXAS1 | |
| SCHEMBL9218920 | 0.85 | KCNH2 (0.43) | KCNH2HRH3TDP1L3MBTL1TBXAS1 | |
| SCHEMBL1751834 | 0.84 | CHEK2 (0.39) | KCNH2PPARGPPARDCHEK2MAPT | |
| SCHEMBL9220790 | 0.81 | MEN1 (0.47) | KCNH2HRH3TDP1L3MBTL1TBXAS1 | |
| Pirodavir SCHEMBL146440 | 0.80 | HRH3 (0.46) | KCNH2HRH3TDP1L3MBTL1TBXAS1 | |
| SCHEMBL1751628 | 0.80 | SIGMAR1 (0.41) | HRH3 | |
| SCHEMBL9381746 | 0.78 | KCNH2 (0.44) | KCNH2HRH3TDP1L3MBTL1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | claimed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | claimed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | claimed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | claimed |
| US-8410105-B2 | Pyridazinyl amine derivatives, the use thereof in the preparation of picorna virus inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-04-02 | — | — | US | disclosed |
| EP-1900735-B1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | INST PHARM & TOXICOLOGY AMMS (CN) | 2012-06-13 | — | — | EP | disclosed |
| US-8076339-B2 | Pyridazine compound; also useful against rhinovirus | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China of Beijing (CN) | 2011-12-13 | — | — | US | disclosed |
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | LI SONG | 2011-03-10 | — | — | US | disclosed |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2008-10-30 | — | — | US | disclosed |
| EP-1900735-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2008-03-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059978-A1 | PYRIDAZINYL AMINE DERIVATIVES, THE USE THEREOF IN THE PREPARATION OF PICORNA VIRUS INHIBITORS | RNASEH1, PIR, HAVCR2 | KCNH2 1609/4885HRH3 1301/4885TDP1 1888/4885 |
| US-20080269232-A1 | Pyridazinyl Amine Derivatives, the Use Thereof in the Preparation of Picorna Virus Inhibitors | RNASEH1, PIR, HAVCR2 | KCNH2 1609/4885HRH3 1301/4885TDP1 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.