Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 11/20 | 1.00 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22450986 | 0.86 | FFAR1 (0.76) | FFAR1CYP26A1CYP26B1CYP2C8MAOB | |
| SCHEMBL19167974 | 0.82 | FFAR1 (1.00) | FFAR1CYP26A1CYP26B1CYP2C8FFAR4 | |
| SCHEMBL19137125 | 0.80 | FFAR1 (1.00) | FFAR1CYP26A1CYP26B1MAOBMAOA | |
| SCHEMBL19166171 | 0.80 | FFAR1 (1.00) | FFAR1CYP26A1CYP26B1MAOBMAOA | |
| SCHEMBL19166584 | 0.79 | FFAR1 (1.00) | FFAR1CYP26A1CYP26B1FFAR4MAOB | |
| SCHEMBL1745020 | 0.79 | FFAR1 (0.77) | FFAR1CYP26A1CYP26B1FFAR4MAOB | |
| SCHEMBL17518890 | 0.79 | FFAR1 (1.00) | FFAR1CYP26A1CYP26B1 | |
| SCHEMBL3013456 | 0.78 | CYP2C8 (0.68) | FFAR1CYP26A1CYP26B1CYP2C8MAOB | |
| SCHEMBL3012615 | 0.76 | FFAR1 (0.63) | FFAR1CYP2C8ALOX5 | |
| SCHEMBL17667824 | 0.74 | FFAR1 (0.60) | FFAR1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177285-B1 | [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20170210727-A1 | [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170210727-A1 | [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-07-27 | — | — | US | disclosed |
| WO-2016022446-A1 | [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210727-A1 | [5,6]-FUSED BICYCLIC ANTIDIABETIC COMPOUNDS | GPR119, GPR55, GPR65 | FFAR1 13/4885CYP26A1 1205/4885CYP26B1 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.