Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15952076 | 0.86 | HTR2A (0.40) | ADRB2CYP3A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL19598016 | 0.86 | HTR2A (0.40) | ADRB2CYP3A4SLC6A2SLC6A3OPRM1 | |
| SCHEMBL12569050 | 0.86 | ACHE (0.52) | DPP4MAPK1ACHEIDO1AOC3 | |
| SCHEMBL3254719 | 0.86 | ACHE (0.52) | DPP4MAPK1ACHEIDO1AOC3 | |
| SCHEMBL3259002 | 0.86 | ACHE (0.52) | DPP4MAPK1ACHEIDO1AOC3 | |
| SCHEMBL17519156 | 0.82 | OPRM1 (0.49) | ADRB2OPRM1OPRK1DPP4IDO1 | |
| SCHEMBL19619720 | 0.79 | SLC6A4 (0.44) | SLC6A2SLC6A3SLC6A4DPP4KMT2A | |
| SCHEMBL23428902 | 0.78 | CYP3A4 (0.42) | CYP3A4SLC6A2SLC6A3OPRM1OPRK1 | |
| SCHEMBL17519152 | 0.78 | OPRL1 (0.43) | ADRB2OPRM1OPRK1DPP4IDO1 | |
| SCHEMBL17519158 | 0.77 | CASR (0.41) | HTR2AHTR2BDPP4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647702-B2 | Aryl-substituted imidazoles | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190345141-A1 | ARYL-SUBSTITUTED IMIDAZOLES | ST JUDE CHILDRENS RES HOSPITAL (US) | 2019-11-14 | — | — | US | disclosed |
| EP-2621275-B1 | ARYL-SUBSTITUTED IMIDAZOLES | ST JUDE CHILDRENS RES HOSPITAL (US) | 2018-03-28 | — | — | EP | disclosed |
| US-9822100-B2 | Aryl-substituted imidazoles | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-11-21 | — | — | US | disclosed |
| US-20160297800-A1 | ARYL-SUBSTITUTED IMIDAZOLES | ST JUDE CHILDREN'S RES HOSPITAL (US) | 2016-10-13 | — | — | US | disclosed |
| US-9266860-B2 | Aryl-substituted imidazoles | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2016-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345141-A1 | ARYL-SUBSTITUTED IMIDAZOLES | MDM2, TP53, MDM4 | ADRB2 4051/4885CYP3A4 1488/4885SLC6A2 4334/4885 |
| US-10647702-B2 | Aryl-substituted imidazoles | MDM2, TP53, MDM4 | ADRB2 4051/4885CYP3A4 1488/4885SLC6A2 4334/4885 |
| US-20160297800-A1 | ARYL-SUBSTITUTED IMIDAZOLES | MDM2, TP53, MDM4 | ADRB2 4051/4885CYP3A4 1488/4885SLC6A2 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.