Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259002 | 0.83 | ACHE (0.52) | DPP4ACHEAOC3ACP3ALDH1A1 | |
| SCHEMBL3254719 | 0.83 | ACHE (0.52) | DPP4ACHEAOC3ACP3ALDH1A1 | |
| SCHEMBL12569050 | 0.83 | ACHE (0.52) | DPP4ACHEAOC3ACP3ALDH1A1 | |
| SCHEMBL19619722 | 0.81 | SLC6A4 (0.43) | SLC6A4MAOASLC6A2SLC6A3DPP4 | |
| SCHEMBL17519154 | 0.79 | ADRB2 (0.45) | SLC6A4SLC6A2SLC6A3DPP4ACHE | |
| SCHEMBL17519158 | 0.75 | CASR (0.41) | DPP4ACHEAOC3ACP3HTT | |
| SCHEMBL11475525 | 0.74 | ROCK1 (0.40) | SLC6A4ACHEAOC3ACP3ALDH1A1 | |
| SCHEMBL23241790 | 0.74 | AOC3 (0.46) | DPP4ACHEAOC3ACP3ALDH1A1 | |
| SCHEMBL19998570 | 0.73 | IDO1 (0.47) | DPP4ACP3HTTKMT2A | |
| SCHEMBL11003398 | 0.71 | ACHE (0.52) | ACHEAOC3ACP3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647702-B2 | Aryl-substituted imidazoles | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-05-12 | — | — | US | disclosed |
| US-9822100-B2 | Aryl-substituted imidazoles | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647702-B2 | Aryl-substituted imidazoles | MDM2, TP53, MDM4 | SLC6A4 3060/4885MAOA 2382/4885SLC6A2 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.