Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 6/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | AMD1 | P17707 | 2/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15395684 | 0.84 | PI4KA (0.62) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL26533854 | 0.79 | AHCY (0.40) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL31756731 | 0.79 | RXFP1 (0.49) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL31756630 | 0.79 | RXFP1 (0.49) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL31756696 | 0.78 | PI4KA (0.55) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL26811459 | 0.78 | PI4KA (0.55) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL26811445 | 0.78 | PI4KA (0.55) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970148 | 0.78 | PI4KA (0.62) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1802098 | 0.78 | RXFP1 (0.37) | AHCYPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL22883255 | 0.77 | AHCY (0.64) | AHCYPI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160045531-A1 | COMBINATION THERAPY FOR TREATING CANCER | Epizyme, Inc. | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160045531-A1 | COMBINATION THERAPY FOR TREATING CANCER | DOT1L, ASH1L, CARM1 | AHCY 505/4885PI4KA 1540/4885PI4K2B 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.