Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | ESRRB | O95718 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19201061 | 0.87 | CYP19A1 (0.50) | NPC1RAB9AGAATAAR1PTGS2 | |
| SCHEMBL17523633 | 0.84 | ESRRB (0.53) | NPC1RAB9AGAAESRRBSMN1; SMN2 | |
| SCHEMBL17523669 | 0.83 | ESRRB (0.65) | NPC1RAB9AESRRBESRRGKDM1A | |
| SCHEMBL19181334 | 0.81 | LMNA (0.59) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL17506011 | 0.81 | CASR (0.57) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL17505999 | 0.81 | PTGS2 (0.51) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL17506010 | 0.81 | CASR (0.57) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL17523976 | 0.81 | LMNA (0.59) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL19181333 | 0.81 | PTGS2 (0.51) | NPC1RAB9APTGS2ESRRBALDH1A1 | |
| SCHEMBL17506005 | 0.80 | CYP19A1 (0.59) | PTGS2ESRRBALDH1A1SMN1; SMN2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | THE PENN STATE RESEARCH FOUNDATION | 2017-08-03 | — | — | US | disclosed |
| WO-2016022325-A1 | NOVEL TRIARYLETHYLENE COMPOUNDS AND METHODS USING SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | CYP46A1, GSTA2, GSTA1 | NPC1 23/4885RAB9A 2537/4885GAA 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.