Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19640183 | 0.88 | PRKDC (0.70) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL19640177 | 0.86 | PRKDC (0.72) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL27002137 | 0.86 | ALDH1A1 (0.67) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1620382 | 0.86 | LMNA (0.87) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL14835649 | 0.86 | LMNA (0.87) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8027591 | 0.85 | PRKDC (0.47) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL17529510 | 0.85 | PRKDC (0.47) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8293084 | 0.84 | ALDH1A1 (0.63) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL515642 | 0.83 | PRKDC (1.00) | PRKDCLMNAALDH1A1MAPTL3MBTL1 | |
| SCHEMBL13299039 | 0.83 | ALDH1A1 (0.49) | PRKDCLMNAALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170266172-A1 | Compositions and Uses of Amidine Derivatives | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-09-21 | — | — | US | disclosed |
| WO-2016029214-A9 | COMPOSITIONS AND USES OF AMIDINE DERIVATIVES | BIOCRYST PHARMACEUTICALS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| WO-2016029216-A2 | METHOD FOR PRODUCING AMIDINE DERIVATIVES | BIOCRYST PHARMACEUTICALS, INC. (US) | 2016-02-25 | — | — | WO | disclosed |
| WO-2016029214-A1 | COMPOSITIONS AND USES OF AMIDINE DERIVATIVES | BIOCRYST PHARMACEUTICALS, INC. (US) | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266172-A1 | Compositions and Uses of Amidine Derivatives | HRH3, HRH2, HRH1 | PRKDC 4384/4885LMNA 1500/4885ALDH1A1 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.