Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | ASPH | Q12797 | 5/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12985283 | 0.72 | KDM4E (0.43) | KDM4EASPHKDM8MAPTALDH1A1 | |
| SCHEMBL984268 | 0.70 | PIN1 (0.52) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL27755478 | 0.69 | PIN1 (0.51) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL27928599 | 0.69 | PIN1 (0.51) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL27755564 | 0.69 | PIN1 (0.51) | KDM4EMAPTALDH1A1CYP3A4ALOX15 | |
| SCHEMBL14437988 | 0.68 | CYP2A6 (0.33) | — | |
| SCHEMBL29537821 | 0.68 | DYRK1A (0.37) | ADORA2A | |
| SCHEMBL31148071 | 0.68 | LMNA (0.33) | MAPTCYP3A4PIN1 | |
| SCHEMBL8980290 | 0.68 | PIN1 (0.39) | KDM4EALDH1A1L3MBTL1PIN1MEN1 | |
| SCHEMBL15902280 | 0.68 | PIN1 (0.36) | ALDH1A1PIN1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990055-B1 | COMPOSITION COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 AGONIST FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR FOR SHRINKING IT | UNIV KYOTO (JP) | 2019-06-05 | — | — | EP | disclosed |
| US-9629834-B2 | Medicinal composition for inhibiting formation and/or enlargement of cerebral aneurysm or shrinking same | KYOTO UNIVERSITY (JP) | 2017-04-25 | — | — | US | disclosed |
| US-20160113917-A1 | MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME | KYOTO UNIVERSITY (JP) | 2016-04-28 | — | — | US | disclosed |
| EP-2990055-A1 | MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME | Kyoto University (JP) | 2016-03-02 | — | — | EP | disclosed |