Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 4/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | KRAS | P01116 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713286 | 0.84 | CDK2 (0.36) | CDK2KCNH2OPRK1KITSYK | |
| SCHEMBL713285 | 0.84 | CDK2 (0.36) | CDK2KCNH2OPRK1KITSYK | |
| SCHEMBL17530799 | 0.84 | OPRK1 (0.38) | OPRK1AKT1 | |
| SCHEMBL17530810 | 0.80 | AKT1 (0.45) | OPRK1AKT1KRAS | |
| SCHEMBL17530857 | 0.79 | IDH1 (0.34) | OPRK1PIK3CDIDH1 | |
| SCHEMBL715221 | 0.78 | KIT (0.39) | KCNH2KITTRPV1PIK3CDAKT1 | |
| SCHEMBL17530778 | 0.77 | ALDH1A1 (0.37) | OPRK1TRPV1IDH1KRAS | |
| SCHEMBL17530766 | 0.77 | MAP4K4 (0.40) | OPRK1PIK3CDAKT1 | |
| SCHEMBL15899831 | 0.75 | PIK3CD (0.39) | TRPV1PIK3CD | |
| SCHEMBL17530794 | 0.75 | KIT (0.35) | OPRK1KITPIK3CDIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403847-B1 | TRIAZINE DERIVATIVES AS KINASE INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2016-03-02 | — | — | EP | claimed |