Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530782 | 0.89 | OPRK1 (0.40) | OPRK1KDM4EALDH1A1TDP1MAPK8 | |
| SCHEMBL17530810 | 0.85 | AKT1 (0.45) | OPRK1AKT1ITGB2ICAM1ITGAL | |
| SCHEMBL17530784 | 0.84 | CDK2 (0.35) | OPRK1AKT1 | |
| SCHEMBL715482 | 0.84 | OPRK1 (0.39) | OPRK1KDM4EALDH1A1TDP1MAPK8 | |
| SCHEMBL715483 | 0.84 | OPRK1 (0.39) | OPRK1KDM4EALDH1A1TDP1MAPK8 | |
| SCHEMBL15899981 | 0.81 | GPR6 (0.39) | OPRK1LMNATP53 | |
| SCHEMBL15327057 | 0.81 | STAT3 (0.42) | OPRK1NPC1RAB9AMAPTLMNA | |
| SCHEMBL17530857 | 0.80 | IDH1 (0.34) | OPRK1 | |
| SCHEMBL715809 | 0.76 | KRAS (0.40) | OPRK1 | |
| SCHEMBL17530769 | 0.75 | MAPT (0.45) | OPRK1KDM4EALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403847-B1 | TRIAZINE DERIVATIVES AS KINASE INHIBITORS | UCB BIOPHARMA SPRL (BE) | 2016-03-02 | — | — | EP | claimed |