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Sugi Predict / Compounds / Dimethylformamide

Dimethylformamide

Dimethylformamide

SCHEMBL175327

CCc1ccc(C[Zn+])cc1.CN(C)C=O.[Br-]

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.36
▸ EGFR P00533 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ LMNA P02545 2/20 0.36
▸ MAPT P10636 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ CA2 P00918 1/20 0.35
▸ TP53 P04637 2/20 0.34
▸ TAAR1 Q96RJ0 1/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ APOBEC3G Q9HC16 1/20 0.34
▸ MGLL Q99685 2/20 0.33
▸ CYP2A6 P11509 1/20 0.33
▸ PLK1 P53350 1/20 0.33
▸ NISCH Q9Y2I1 1/20 0.33
▸ LPL P06858 1/20 0.33
▸ LIPG Q9Y5X9 1/20 0.33
▸ UCHL1 P09936 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL158406 0.82 TP53 (0.48) ALDH1A1EGFRTSHRLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL7801045 0.78 TP53 (0.48) ALDH1A1EGFRTSHRLMNASMN1; SMN2
Dimethylformamide SCHEMBL175329 0.78 HPGD (0.39) HPGDALDH1A1EGFRTSHRLMNA
Ethylbenzene SCHEMBL14965882 0.77 TP53 (0.64) ALDH1A1TSHRLMNAMAPTSMN1; SMN2
Dimethylformamide SCHEMBL175328 0.74 HPGD (0.37) HPGDALDH1A1EGFRTSHRLMNA
SCHEMBL8361530 0.71 HPGD (0.40) HPGDALDH1A1TSHRLMNAMAPT
Trimethylammonium SCHEMBL27719445 0.69 TP53 (0.56) HPGDALDH1A1TSHRLMNASMN1; SMN2
SCHEMBL6688169 0.68 ALDH1A1 (0.40) HPGDALDH1A1EGFRLMNAMAPT
SCHEMBL4634848 0.68 ALDH1A1 (0.40) HPGDALDH1A1EGFRLMNAMAPT
Formic Acid SCHEMBL27430708 0.68 ALDH1A1 (0.54) HPGDALDH1A1EGFRLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120058941-A1 GLUCOPYRANOSIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2012-03-08 — — US disclosed
US-7943788-B2 Including the antidiabetic, antiobesity sodium glucose transport inhibitor Canagliflozin (1-( beta -D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene) MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-05-17 — — US disclosed
US-20110105424-A1 GLUCOPYRANOSIDE COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058941-A1 GLUCOPYRANOSIDE COMPOUND UGGT1, B3GAT3, FUT6 HPGD 612/4885ALDH1A1 873/4885EGFR 2152/4885
US-20110105424-A1 GLUCOPYRANOSIDE COMPOUND UGGT1, B3GAT3, FUT6 HPGD 612/4885ALDH1A1 873/4885EGFR 2152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.