Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 2/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.40 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205296 | 0.77 | SYK (0.56) | SYK | |
| SCHEMBL15819813 | 0.77 | SYK (0.47) | SYKIDH2TEAD1ALDH1A1GAA | |
| SCHEMBL901922 | 0.76 | ROCK1 (0.45) | SYKIDH2AURKAALDH1A1GAA | |
| SCHEMBL13726067 | 0.75 | SYK (0.62) | SYKIDH2MAP3K12 | |
| SCHEMBL15829252 | 0.74 | SYK (0.49) | SYKIDH2TEAD1NOS3NOS2 | |
| SCHEMBL13823683 | 0.73 | IDH2 (0.49) | SYKIDH2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL13737619 | 0.72 | NOS3 (0.49) | SYKIDH2NOS3NOS2MAP3K12 | |
| SCHEMBL1704454 | 0.71 | KARS1 (0.50) | SYKIDH2TEAD1AURKANOS3 | |
| SCHEMBL27115514 | 0.71 | SYK (0.52) | SYKIDH2AURKACLK2CLK4 | |
| SCHEMBL31121348 | 0.70 | NOS3 (0.52) | SORT1ALDH1A1GAAL3MBTL1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745295-B2 | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160060255-A1 | THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS | MERCK CANADA INC. (CA) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060255-A1 | THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS | SYK, TYRO3, BTK | SYK 1/4885IDH2 3651/4885TEAD1 1515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.