Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 9/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13823683 | 0.81 | IDH2 (0.49) | SYKIDH2MAP3K12KDM4EALDH1A1 | |
| SCHEMBL901918 | 0.77 | KMT2A (0.59) | ROCK1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL17536757 | 0.76 | SYK (0.45) | SYKIDH2KDRMAP3K12KDM4E | |
| SCHEMBL15819813 | 0.75 | SYK (0.47) | SYKIDH2MAP3K12ALDH1A1GAA | |
| SCHEMBL28994210 | 0.74 | BTK (0.57) | KDRKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL13726067 | 0.74 | SYK (0.62) | SYKIDH2MAP3K12 | |
| SCHEMBL12893944 | 0.73 | ROCK1 (0.53) | ROCK1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL15829252 | 0.73 | SYK (0.49) | SYKIDH2MAP3K12 | |
| SCHEMBL24349565 | 0.72 | GPR52 (0.66) | ROCK1AURKAP2RY1 | |
| SCHEMBL13737619 | 0.71 | NOS3 (0.49) | SYKIDH2MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |