Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17537196 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537126 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537193 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537215 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537092 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537156 | 1.00 | TSHR (0.50) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL26907900 | 0.89 | GABRA1 (0.41) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17565218 | 0.88 | GABRA1 (0.54) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17565217 | 0.88 | GABRA1 (0.54) | TSHRGABRA1GABRB2CYP1A2HIF1A | |
| SCHEMBL17537205 | 0.88 | GABRA1 (0.54) | TSHRGABRA1GABRB2CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189834-B1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE LTD (SG) | 2024-01-17 | — | — | EP | disclosed |
| US-20230118143-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| WO-2021239130-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | 四川海思科制药有限公司 | 2021-12-02 | — | — | WO | disclosed |
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | HAISCO CHENGDU PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-08-04 | — | — | US | disclosed |
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | HAISCO CHENGDU PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-08-04 | — | — | US | disclosed |
| EP-2995604-B1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |
| CN-105579034-B | A kind of GABAA receptor potentiators are used to prepare the purposes in the medicine of sedation anesthesia | 海思科医药集团股份有限公司 | 2018-05-15 | — | — | CN | disclosed |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE. LTD. (SG) | 2017-10-12 | — | — | US | disclosed |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE. LTD. (SG) | 2017-10-12 | — | — | US | disclosed |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE. LTD. (SG) | 2017-10-12 | — | — | US | disclosed |
| US-9517988-B2 | Phenol derivative and preparation method and use in medicine thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-12-13 | — | — | US | disclosed |
| US-9517988-B2 | Phenol derivative and preparation method and use in medicine thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-12-13 | — | — | US | disclosed |
| CN-104507899-B | Phenol derivative, preparation method and medical application thereof | 四川海思科制药有限公司 | 2016-11-30 | — | — | CN | disclosed |
| CN-105579034-A | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-05-11 | — | — | CN | disclosed |
| EP-2995604-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
| EP-2995604-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
| WO-2016034079-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | 四川海思科制药有限公司 | 2016-03-10 | — | — | WO | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | GABRA1, GABRA5, GABRA2 | TSHR 456/4885GABRA1 1/4885GABRB2 9/4885 |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | CYP2D6, CYP2B6, CYP2A6 | TSHR 3827/4885GABRA1 2665/4885GABRB2 3304/4885 |
| US-20230118143-A1 | PHARMACEUTICAL PREPARATION AND PREPARATION METHOD THEREFOR | GABRA1, GABRR1, GABARAPL1 | TSHR 160/4885GABRA1 1/4885GABRB2 17/4885 |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | GABRA1, GABRA5, GABRA2 | TSHR 456/4885GABRA1 1/4885GABRB2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.