Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19442573 | 0.95 | BCHE (0.45) | RETKDRACKR3NPSR1MEN1 | |
| SCHEMBL17511304 | 0.83 | HDAC3 (0.47) | RETKDRMAPTHDAC3HDAC1 | |
| SCHEMBL19440809 | 0.82 | NPC1 (0.56) | MAPTMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL13740181 | 0.80 | TDP1 (0.47) | NPSR1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL17883357 | 0.80 | ITK (0.53) | MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL19442587 | 0.79 | NPC1 (0.41) | — | |
| SCHEMBL19440874 | 0.79 | RET (0.41) | RETKDRMAPTHDAC3HDAC1 | |
| SCHEMBL17540249 | 0.79 | HIF1A (0.67) | KMT2AHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL19440851 | 0.79 | LMNA (0.46) | MAPTMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL19440792 | 0.78 | MEN1 (0.43) | MAPTMEN1KMT2AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505729-B2 | Isoxazole analogs as mediators of transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-9505729-B2 | Isoxazole analogs as mediators of transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | VANDERBILT UNIVERSITY | 2016-02-25 | — | — | US | disclosed |
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | VANDERBILT UNIVERSITY | 2016-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | CDH1, VIM, EPCAM | RET 2926/4885KDR 3560/4885ACKR3 1595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.