Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17540324 | 0.91 | ALDH1A1 (0.56) | ALDH1A1MAPK1RAB9AHSD17B10ADRB2 | |
| SCHEMBL14254837 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPK1RAB9AHSD17B10USP2 | |
| SCHEMBL18115572 | 0.82 | RAB9A (0.65) | ALDH1A1RAB9AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL10137686 | 0.81 | RAB9A (0.74) | ALDH1A1MAPK1RAB9AHSD17B10USP2 | |
| SCHEMBL11313977 | 0.80 | POLB (0.64) | ALDH1A1RAB9AHSD17B10SMN1; SMN2TSHR | |
| SCHEMBL16068453 | 0.78 | RAB9A (0.75) | ALDH1A1RAB9AHSD17B10ADRB2ADRB1 | |
| SCHEMBL13406087 | 0.75 | ALDH1A1 (0.62) | ALDH1A1RAB9AHSD17B10SMN1; SMN2TSHR | |
| SCHEMBL7152680 | 0.75 | ALDH1A1 (0.64) | ALDH1A1MAPK1RAB9AHSD17B10USP2 | |
| SCHEMBL12545738 | 0.74 | PARP1 (0.60) | ALDH1A1RAB9AHSD17B10SMN1; SMN2TSHR | |
| SCHEMBL30668647 | 0.74 | PARP1 (0.60) | ALDH1A1RAB9AHSD17B10SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349590-A1 | MEROPENEM DERIVATIVES AND USES THEREOF | OXFORD FINANCE LLC | 2017-12-07 | — | — | US | disclosed |
| US-9725451-B2 | Meropenem derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160039823-A1 | Meropenem Derivatives and Uses Thereof | KALA PHARMACEUTICALS, INC. (US) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039823-A1 | Meropenem Derivatives and Uses Thereof | SLCO1B1, SLCO2B1, ABCB11 | ALDH1A1 2014/4885MAPK1 3396/4885RAB9A 585/4885 |
| US-20170349590-A1 | MEROPENEM DERIVATIVES AND USES THEREOF | SLCO1B1, SLCO2B1, ABCB11 | ALDH1A1 2014/4885MAPK1 3396/4885RAB9A 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.