Sugi Predict

Sugi Predict / Compounds / SCHEMBL1754056

SCHEMBL1754056

SCHEMBL1754056

COC(=O)c1ccc(CBr)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.46
▸ GAA P10253 4/20 0.46
▸ KDM4E B2RXH2 3/20 0.46
▸ HPGD P15428 3/20 0.46
▸ HSD17B10 Q99714 3/20 0.46
▸ MAPT P10636 2/20 0.46
▸ ALOX15 P16050 1/20 0.46
▸ TSHR P16473 1/20 0.46
▸ CYP4F2 P78329 2/20 0.45
▸ CYP4A11 Q02928 2/20 0.45
▸ CA12 O43570 3/20 0.43
▸ CA2 P00918 3/20 0.43
▸ CA7 P43166 3/20 0.43
▸ CA9 Q16790 3/20 0.43
▸ CA14 Q9ULX7 3/20 0.43
▸ CA1 P00915 2/20 0.43
▸ PDK2 Q15119 1/20 0.43
▸ PDK4 Q16654 1/20 0.43
▸ HTT P42858 3/20 0.42
▸ CCR6 P51684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29775267 1.00 ALDH1A1 (0.46) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL13182869 0.88 ALDH1A1 (0.47) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL27855193 0.87 GAA (0.44) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL2770254 0.86 CA12 (0.51) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL603667 0.86 ALDH1A1 (0.50) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL1022658 0.86 ALDH1A1 (0.53) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL29943277 0.86 ALDH1A1 (0.53) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL25380017 0.85 ALDH1A1 (0.45) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL15233140 0.85 GAA (0.45) ALDH1A1GAAKDM4EHPGDHSD17B10
SCHEMBL16415450 0.85 LOXL2 (0.54) ALDH1A1GAAKDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637433-B2 Histone deacetylase inhibitors THE UNIVERSITY OF QUEENSLAND (AU) 2026-05-26 — — US disclosed
EP-4638460-A1 BENZIMIDAZOLE DERIVATIVES FOR THE MODULATION OF STING Aculeus Therapeutics Pty Ltd (AU) 2025-10-29 — — EP disclosed
EP-3227271-B1 HETEROCYCLIC DERIVATIVES AND USE THEREOF C&C RES LAB (KR) 2025-08-13 — — EP disclosed
WO-2025060974-A1 N-SULFONYL CARBOXAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海宇道生物技术有限公司 2025-03-27 — — WO disclosed
WO-2025049326-A1 TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 BIOCRYST PHARMACEUTICALS, INC. (US) 2025-03-06 — — WO disclosed
US-20240365736-A1 COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL OERTH BIO LLC (US) 2024-11-07 — — US disclosed
US-20240350643-A1 PROTEIN DEGRADATION AGENT SUZHOU KINTOR PHARMACEUTICALS, INC. (CN) 2024-10-24 — — US disclosed
CN-113754589-B Compositions, methods, and systems for synthesizing and using contrast agents 蓝瑟斯医学影像公司 2024-09-27 — — CN disclosed
CN-112566905-B Substituted phenylpropenyl pyridine derivatives, preparation method and medical application thereof 上海海雁医药科技有限公司 2024-07-30 — — CN disclosed
US-20240245699-A1 PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SERVIER LAB (FR) 2024-07-25 — — US disclosed
US-20040242572-A1 New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2004-12-02 — — US disclosed
WO-2004073612-A2 ESTROGEN RECEPTOR MODULATORS MERCK & CO. INC. (US) 2004-09-02 — — WO disclosed
EP-1389194-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2004-02-18 — — EP disclosed
US-20030095958-A1 Inhibitors of bace VERTEX PHARMACEUTICALS INCORPORATED 2003-05-22 — — US disclosed
WO-2002088101-A2 INHIBITORS OF BACE VERTEX PHARMACEUTICALS INCORPORATED (US) 2002-11-07 — — WO disclosed
EP-0399731-B2 Azaindenes ASTRAZENECA AB (SE) 2001-07-11 — — EP disclosed
EP-0399732-B1 Benzimidazole derivatives ZENECA LTD (GB) 1995-07-26 — — EP disclosed
EP-0399731-B1 Azaindenes ZENECA LTD (GB) 1993-12-08 — — EP disclosed
US-5171748-A For hypertension, cardiovascular disorders IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-12-15 — — US disclosed
EP-0399732-A1 Benzimidazole derivatives ZENECA LIMITED (GB) 1990-11-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030095958-A1 Inhibitors of bace BACE2, BACE1, APP ALDH1A1 2007/4885GAA 38/4885KDM4E 1717/4885
US-20040242572-A1 New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture MCHR2, MCHR1, NPY1R ALDH1A1 3363/4885GAA 206/4885KDM4E 492/4885
US-20240350643-A1 PROTEIN DEGRADATION AGENT MYC, MYCBP, MYCBP2 ALDH1A1 4043/4885GAA 1329/4885KDM4E 2505/4885
US-20240365736-A1 COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL CRBN, LTN1, CBL ALDH1A1 4050/4885GAA 2052/4885KDM4E 1016/4885
US-12637433-B2 Histone deacetylase inhibitors HDAC1, HDAC11, HDAC3 ALDH1A1 1976/4885GAA 1205/4885KDM4E 481/4885
US-20240245699-A1 PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PDCD11, RRM2B, RRM2 ALDH1A1 1180/4885GAA 3506/4885KDM4E 1783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.