Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115005 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RECQLRAB9AUCHL1 | |
| SCHEMBL14720896 | 0.78 | GRM5 (0.46) | SMN1; SMN2NPC1RECQLRAB9AMEN1 | |
| SCHEMBL17542538 | 0.78 | USP30 (0.40) | UCHL1KDM1AESR2NR1H2CHRM4 | |
| SCHEMBL30740727 | 0.77 | HSD11B1 (0.39) | SMN1; SMN2UCHL1MEN1KMT2A | |
| SCHEMBL23906274 | 0.76 | ESR2 (0.47) | SMN1; SMN2NPC1RECQLRAB9ARORC | |
| SCHEMBL6615893 | 0.75 | HDAC1 (0.49) | SMN1; SMN2NPC1RAB9AUCHL1NPSR1 | |
| SCHEMBL17542019 | 0.75 | HDAC1 (0.48) | SMN1; SMN2NPC1RECQLRAB9ARORC | |
| SCHEMBL7405154 | 0.75 | USP2 (0.40) | SMN1; SMN2UCHL1KDM1AHDAC1ESR2 | |
| SCHEMBL7405157 | 0.75 | USP2 (0.40) | SMN1; SMN2UCHL1KDM1AHDAC1ESR2 | |
| SCHEMBL6290081 | 0.72 | MAPT (0.39) | NPC1UCHL1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186224-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. Hoffmann-La Roche AG (CH) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016030310-A1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-03-03 | — | — | WO | disclosed |