Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115005 | 0.81 | SMN1; SMN2 (0.41) | HDAC1NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1602307 | 0.77 | OGA (0.46) | HDAC1HDAC6PIM1ALDH1A1NR1H2 | |
| SCHEMBL20304926 | 0.76 | KMT2A (0.46) | HDAC1HDAC6PIM1ALDH1A1NR1H2 | |
| SCHEMBL20304927 | 0.76 | KMT2A (0.46) | HDAC1HDAC6PIM1ALDH1A1NR1H2 | |
| SCHEMBL20333548 | 0.76 | KMT2A (0.46) | HDAC1HDAC6PIM1ALDH1A1NR1H2 | |
| SCHEMBL30740727 | 0.76 | HSD11B1 (0.39) | ALDH1A1SMN1; SMN2MAPTUCHL1USP30 | |
| SCHEMBL20332701 | 0.75 | NR1H2 (0.48) | HDAC1HDAC6PIM1ALDH1A1NR1H2 | |
| SCHEMBL17542385 | 0.75 | SMN1; SMN2 (0.43) | HDAC1HDAC6NR1H2RAB9ANPC1 | |
| SCHEMBL31357623 | 0.75 | HDAC1 (0.36) | HDAC1HDAC6ALDH1A1NR1H2RAB9A | |
| SCHEMBL21816667 | 0.74 | NR1H2 (0.46) | HDAC1HDAC6PIM1ALDH1A1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395574-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094810-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |