Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544014

SCHEMBL17544014

SCHEMBL17544014

CNCc1cccc(-c2nc3cc(OCc4ccc(OC)cn4)ccc3o2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.46
▸ HPGD P15428 4/20 0.46
▸ RAB9A P51151 4/20 0.46
▸ SMN1; SMN2 Q16637 3/20 0.46
▸ KDM4E B2RXH2 3/20 0.46
▸ HSD17B10 Q99714 3/20 0.46
▸ TP53 P04637 3/20 0.46
▸ NPC1 O15118 3/20 0.46
▸ GLA P06280 1/20 0.46
▸ NFKB1 P19838 1/20 0.46
▸ NFKB2 Q00653 1/20 0.46
▸ RELA Q04206 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46
▸ PDE10A Q9Y233 2/20 0.44
▸ MAPT P10636 3/20 0.44
▸ TSHR P16473 2/20 0.44
▸ MAPK1 P28482 2/20 0.44
▸ CASP3 P42574 1/20 0.44
▸ SENP8 Q96LD8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29680869 1.00 ALDH1A1 (0.46) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL17553863 0.91 MAPT (0.44) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL17544284 0.89 RET (0.43) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL29681081 0.89 RET (0.43) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL19428553 0.88 ALDH1A1 (0.49) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL30427363 0.87 ALDH1A1 (0.46) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL17544101 0.87 ALDH1A1 (0.46) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL30402440 0.87 ALDH1A1 (0.53) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL17544578 0.87 ALDH1A1 (0.53) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E
SCHEMBL23633322 0.85 SMN1; SMN2 (0.58) ALDH1A1HPGDRAB9ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ALDH1A1 3976/4885HPGD 2107/4885RAB9A 1100/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 ALDH1A1 3950/4885HPGD 3538/4885RAB9A 1054/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 ALDH1A1 3949/4885HPGD 2117/4885RAB9A 993/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ALDH1A1 3976/4885HPGD 2107/4885RAB9A 1100/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 ALDH1A1 3949/4885HPGD 2117/4885RAB9A 993/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 ALDH1A1 3976/4885HPGD 2107/4885RAB9A 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.